Holiday Inn Florence is a full-service hotel located in the center of Sheffield, Muscle Shoals, Florence and Tuscumbia in beautiful North Alabama. The Holiday Inn is the ideal location for business and leisure travelers alike. The hotel features 202 spacious guestrooms with all the amenities youve come to expect from Holiday Inn Hotels. Enjoy a delicious meal in the restaurant or relax over a nightcap and listen to live music in the lounge. Holiday Inn Florence looks forward to your stay here.