The Econo Lodge in Hannibal is located in the heart of the city and is adjacent to I-72 and HWY 61. Mark Twain historical sites within minutes. The hotel features a complimentary Continental Breakfast. Several restaurants within a 5 minute drive. Impeccably clean; spacious rooms and friendly service bring back guests who visit each year. Earn FREE nights or flights by joining the easy Choice Frequent Traveller Program.