Welcome to the Holiday Inn Express & Suites, O'Fallon, MO's newest hotel, conveniently located I-40/64 and Hwy K. . During your stay at the Holiday Inn Express & Suites, OFallon, you will enjoy our proximity to local St Louis attractions such as the St. Louis Arch, Ameristar Casino, and Anheuser Busch. You can take in a St Louis Cardinals game at Busch Stadium or a St Louis Rams game at the Edward Jones Dome, just a short drive from the hotel. Holiday Inn Express & Suites OFallon can meet all of your business and leisure needs .